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This matters for interpretation: an intervention whose insulin-sensitizing effect is largely weight-mediated will help women whose insulin resistance is weight-driven more than it helps the intrinsic, lean-PCOS component that persists independent of body mass

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[15] [16] Clinical studies examining the effects of GLP-1 receptor agonists on resting metabolic rate (RMR) and total energy expenditure have produced consistent findings: these medications do not significantly increase metabolic rate

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