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Given these findings, it can be realized that the depicted rise in ER stress markers, especially CHOP, acted supportively with the ongoing exaggerated ROS and inflammatory mediators to induce apoptotic pathways in MSG-intoxicated group, which is supported by the remarkable upregulation in the gene expression of pro-apoptotic BAX and downregulation in the gene expression of anti-apoptotic Bcl-2 in this group, compared to normal control group

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Randle et al

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