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HK2 inhibitor 3-BrPA in combination with LXR- agonist GW3965 could effectively alleviate the synovial lipotoxic microenvironment by blocking glycolytic flux and activating ABCA1-mediated cholesterol efflux ( Current research has explored the combined application of HK2 inhibitors (e.g., 2-DG) and AMPK agonists (e.g., Metformin) in RA models, demonstrating synergistic inhibitory effects on synovitis and bone erosion