Diurnal variations in mood have been seen in naturalistic conditions ( Acute or chronic dysfunctions of the circadian timekeeping system (e.g., Eastbound travels across time-zones and rotating night shift workers, respectively) impact the organism with consequences at different biological scales, i.e., cellular, tissue, and systemic level
These included nausea, diarrhea, vomiting, constipation, and decreased appetite
Diabetes mellitus-related gut dysbiosis is linked to breakdown of the epithelial barrier and a reduction in short-chain fatty acids
To overcome this limitation, GLP-1 analogs have undergone extensive structural modifications to render them resistant to degradation while replicating the pharmacological functions [6, 7]