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[115] This functionality is lost in vitamin B 12 deficiency, resulting in an increased homocysteine level and the trapping of folate as 5-methyl-tetrahydrofolate, from which THF (the active form of folate) cannot be recovered

This makes it relevant for anyone whose sleep problems stem from stress, irregular schedules, or cognitive overactivation at bedtime

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This is the kind of detail that rarely appears in celebrity coverage but matters enormously to the thyroid patient reading about Clarkson's experience and wondering whether a GLP-1 drug would work for them