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Under the stimulation of insulin, pancreatic fat consistently secretes inflammatory factors such as IL-6, TNF to alter chronic inflammation in the pancreas, which finally leads to oncogenic mutation and the onset of PDA (Murphy et al., 2018

Dihexa works through HGF/c-Met allosteric potentiation with structural synaptogenesis as the primary outcomeit has no human clinical trial data and effects in animals required multi-week treatment for full expression

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These observations help researchers form hypotheses about potential mechanisms of action, but they do not establish clinical relevance or real world outcomes