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Redox homeostasis and antioxidant signaling: a metabolic interface between stress perception and physiological responses

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63,64,65,66,67 Because RNase H is active in the nucleus and cytoplasm, ASOs can also target other transcripts, such as long non-coding RNAs

Interestingly, in trajectory 3 after 750 ns, the dynamic ECD moves back toward the TMD and is stabilized in a conformation that forms contacts mainly with ECL1, resembling the closed ECD conformation in the crystal structure