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The present narrative review is part of a larger project, and we present this companion article that provides a detailed examination of the literature beyond bioactives for estrogen-deficient skin covering the polyphenols (i.e., daidzein, genistein, equol, and resveratrol) [9]

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Despite these challenges, pursuing further investigation into antioxidant enzymes, specifically superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase 1 (GPX1), as well as inflammatory markers such as interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-), remains crucial