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What to Expect: How Your Body Will Feel First Few Weeks: Its normal to experience mild nausea, stomach discomfort, or changes in appetite as your body adjusts to the medication

The most significant clinical data for retatrutide to date comes from a Phase 2 randomised controlled trial published in the New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023)

It was tested on healthy volunteers and on a small cohort of patients with Crohns disease