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Figure 1 2.1 Structure of HIF in hypoxic microenvironment In hypoxic conditions, HIF serves as the primary signaling molecule, with HIF-1 exhibiting high sensitivity to low oxygen and serving as the core regulatory molecule in the bodys response to hypoxia (6)

M., Dillard, C., & German, J

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Hemoglobin has to remain in the redox state, since methemoglobin is unable to carry oxygen but is also prone, through autocatalytic oxidative reactions, to lose heme (ironprotoporphyrin IX) [206]