Next-generation combinations (GLP-1 + GIP, triple agonists with glucagon, GLP-1 + amylin) are even more powerful and represent the future of metabolic therapeutics - potentially 25-30% body weight reduction with profound improvements in liver fat, insulin sensitivity, and cardiovascular markers
Garvey WT, Frias JP, Jastreboff AM, le Roux CW, Sattar N, Aizenberg D, Mao H, Zhang S, Ahmad NN, Bunck MC, Benabbad I, Zhang XM, Abalos FH, Manghi FCP, Zaidman CJ, Vico ML, Aizenberg D, Costanzo PR, Serra LP,
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Survodutide (BI 456906) is a GLP-1R/GCGR dual agonist developed by Boehringer Ingelheim, with outcomes of a phase 2 trial in MASLD and a phase 1 trial in cirrhosis published almost simultaneously with tirzepatide