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Interestingly, reduced expression of enzymes involved in FA transport and -oxidation was paralleled by substantial modifications in PPARs, a family of FA-activated nuclear receptors, with attenuated expression of Ppar and Ppar and a dramatic increase in Ppar/ expression in cKOt mice (Supplemental Figure 6)

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In one multicenter study, GLP-1 medicine use was associated with lower risks of major heart events, blood clots, kidney disease progression, and death compared with DPP-4 inhibitor medicines in patients with lupus and type 2 diabetes