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The extended-release (ER) formulation encapsulates exenatide within biodegradable poly(D, L-lactide-co-glycolide) (PLGA) microspheres, which form a polymeric matrix that allows sustained drug release following SC administration [13, 14, 58]

Ensure adequate protein intake from the outset (aim for 1.2g per kilogram of body weight as a minimum), and address any existing nutritional deficiencies particularly iron and vitamin D before starting treatment

Due to (temporarily) reduced sodium reuptake while continuously promoting glucosuria, these drugs induce a reduction in GFR likely via activation of tubuloglomerular feedback (TGF) that may represent reduced intraglomerular pressure [5]

The latest data show that one in four report having started shopping at a different grocery store since starting the medication