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The association between UPF and the development of ASD may arise as a consequence of dietary contaminants in UPF, such as acrylamide, leading to changes in lipid regulation and metabolism ( 4.1 Summary of key pathophysiological mechanisms UPFs may lead to several pathophysiological changes across several important cellular and biochemical pathways, which have been implicated in the development of psychiatric disorders

Among these, serum/glucocorticoid-regulated kinase 1 (SGK1) expression patterns in circulating endothelial cells showed consistency between healthy individuals and CHD patients

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Cisplatin nephrotoxicity leads to decreased creatinine clearance, increased serum creatinine levels, increased urea levels, increased urine output, and decreased glomerular filtration rate [100,101]