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Prog Neuropsychopharmacol Biol Psychiatry 91:94102 Draganov M, Vives-Gilabert Y, de Diego-Adelio J et al (2020) Glutamatergic and GABA-ergic abnormalities in First-episode depression

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From this research it seems that the best explanations may be through the potential reset of a disrupted methionine-folate cycle and aiding in the removal of toxic metals and chemicals from the brain

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