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4.1 Iron chelators Iron chelator has the ability to become a stable complex through strong binding with iron ion, thus preventing too much free iron ion from participating in redox reaction in cells to produce ROS, initiate lipid peroxidation, cause cell oxidative damage and trigger ferroptosis

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However, this in vitro observation may not be valid for the brain in vivo , and in glutamate-dehydrogenase knock-out mice glutamate oxidation, determined in astrocyte cultures is reduced, but absolutely not abolished (Frigerio et al., 2011

Modification role of dietary antioxidants in the association of high red meat intake and lung cancer risk: evidence from a cancer screening trial