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| Vrije Universiteit Amsterdam | Nrf2 activation and enzyme regulation (2011) | View Study (PMID: 21967611) Written by: Nukleo Research Team | Based on peer-reviewed research | Last updated: March 26, 2026 What is DPP-4 Enzyme

Its inclusion in the Category 2 restricted list has drawn criticism from clinicians who point to its legitimate international approval record as evidence that the safety concerns cited by the FDA are inconsistent with the global clinical literature