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The emergence of small-molecule GLP-1 agonists, such as orforglipron, which can be taken without fasting restrictions, may further reshape the competitive landscape

Although some plans may exclude GLP-1s for weight loss, they might approve them for diabetes or sleep apnea

(Just think of smartphones and ultraprocessed foods.) Still, GLP-1s may be a medical first: a blockbuster drug class, enthusiastically taken up by millions of people not for one or a few uses but, it appears, a multitude

However, when lip changes persist over time, they may be a sign of a condition called actinic cheilitis, which is related to long term sun exposure