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Supporting these findings, a recent PET (positron emission tomography) imaging study by (Kato et al., 2023) demonstrated a significant reduction in Complex I availability in the anterior cingulate cortex of ASD individuals, reinforcing the hypothesis that compromised mitochondrial respiration plays a key role in ASD pathophysiology

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Detergent-resistant microdomains determine the localization of sigma-1 receptors to the endoplasmic reticulum-mitochondria junction

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