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Description

TIRZEPATIDE Tirzepatide is a co-agonist of the incretin hormones GLP-1 and GIP approved by the FDA for the treatment of type 2 diabetes mellitus (T2DM) and weight loss 28

Over 12 months, steroid dependence was significantly lower among GLP-1 users compared with nonusers (52.9% vs 62.8%, respectively)

The main difference between the different trials conducted so far is the potency of GLP-1 drugs administered

Notably, the liver is a major target organ for the metabolic effects of insulin and exerts a first-pass extraction of up to 85% of insulin delivered by the portal vein ( Figure 1A )