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Particularly, in some embodiments, hydrophilic active agents are released more quickly, e.g., approximately 50% of drug release after 24 hours, the remainder released over approximately 5 days, whereas hydrophobic agents are released more slowly, e.g., approximately 80% after 8 weeks

Low B12 has been associated with sleep disturbances and with mood symptoms such as low mood or anxiety, and correcting a confirmed deficiency may help some people in these areas

Maintenance doses are then tailored to keep those levels topped up, and their duration of effect is directly tied to the prescribed frequency (e.g., a shot every 12 weeks for many)

Hunt C, Hartford SA, White D, Pefanis E, Hanna T, Herman C, et al