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If a patient is suffering from reflux, they should definitely be getting that looked at, because solving that problem from the point of view of rebuilding teeth that have been damaged by acids is complicated and expensive. Holden also highlights another, more surprising consideration: nutrition

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Pathological characteristics of AD include extracellular A accumulation and the hyperphosphorylated microtubule-associated protein, tau (p-Tau) [218]

The unknown rate constants for R 1 , R 2 , R 3 , R 4 and R 5 for the respective models were fitted using the LSQNONLIN function in MATLAB, a non-linear least squares solver