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As illustrated in Figures 8A, B, HU forms two hydrogen bonds with Glu173 of S6K with the length of 3.13 and 3.21 , respectively

Oeckl et al., 2012), while another found a non-significant trend toward higher CSF cGMP levels in PD patients when compared with controls and higher levels in levodopa-treated PD patients compared with those without levodopa treatment (Navarro et al., 1998)

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Future research will focus on three directions: Further exploring effects in humans and conducting clinical trials to verify safety and efficacy in human anti-aging, supporting translational application