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Data Animal Data Embryo-fetal development was evaluated in female rats administered setmelanotide subcutaneously during mating to end of major organogenesis (14 days prior to mating to gestation day 17) at doses of 0.5, 3, and 5 mg/kg/day, resulting in exposures up to 11 times the human exposure at MRHD of 3 mg, based on AUC

Another found semaglutide is effective in reducing alcohol intake and modulating binge-like alcohol drinking in mice, while a third study examined how lab mice taking different GLP-1 medications can more successfully resist cocaine

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It provides context for a provider conversation about the GLP-1 pathway generally