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Garcia-Hernandez G

Preclinical studies from our group and others have demonstrated that dual inhibition of IDO1 and TDO2, especially when combined with anti-PD1 therapy, can significantly improve survival in mouse models of lung cancer (47, 48)

This isomerization is relevant to the phototherapy of jaundiced newborns: the E,Z-isomers of bilirubin formed upon light exposure are more soluble than the unilluminated Z,Z-isomer, as the possibility of intramolecular hydrogen bonding is removed