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The most common side effects are extremely mild and infrequent, primarily involving occasional skin irritation, mild redness, or transient tingling sensation in a small percentage of users, typically resolving without intervention and not requiring discontinuation
However, it is not approved for human use by the FDA and is banned in competitive sports by WADA
In fact, platelet-activating factor binding to PAFr leads to the production of inositol trisphosphate (IP3) through the phosphatidylinositol cycle, which in turn binds to inositol 1,4,5-triphosphate receptor type 1 (IP3R1) to induce the release of Ca 2+ stored in the endoplasmic reticulum (Kroegel et al., 1989
M.HogdallE
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