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For the IL-17A/IL-22 fusion, significant protein engineering was required to obtain a dual activity profile in in vitro assays and to limit the peptide degradation during production, a phenomenon frequently observed for peptide fusion molecules expressed in transfected cells 30

This guide aggregates the available rodent PK data, protocol-design implications, and known gaps

Comparative effectiveness of GLP-1 receptor agonists on glycemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis

Discontinuation rates at the highest approved doses are also similar among most products, with the exception of orforglipron