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The success of Byetta sparked further research into GLP-1 therapies, leading to the development of other medications, including: Liraglutide (Victoza) : Approved in 2010, liraglutide extends the work of GLP-1 agonists and is also used for weight management

This leads to significant electron leakage, particularly from Complexes I and III, which directly reduces oxygen to superoxide anion (O 2 ) (Xue et al., 2020

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