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[5] [6] When to Seek Medical Advice Patients and carers should contact their GP or diabetes specialist nurse if they experience: Persistent nausea, vomiting, or diarrhoea lasting more than a few days Severe abdominal pain, particularly if radiating to the back Signs of dehydration (dizziness, reduced urine output, confusion) Symptoms of hypoglycaemia (tremor, sweating, confusion) Unexplained weight loss exceeding clinical targets Changes in vision, particularly in those with pre-existing diabetic retinopathy Suspected adverse reactions should be reported via the MHRA Yellow Card scheme

J., Gotze, J

Conclusions, possible consequences and perspectives Measurement of GSH and GSSG, in particular for the calculation of the GSH/GSSG ratio which is considered an excellent index of the oxidative status of a tissue, is plagued by many severe artifacts

Even more striking, nearly 18% of patients end up regaining all or even more of the weight they initially lost