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Interventional radiologists, other surgical colleagues familiar with image guidance techniques, and ultrasound technicians are all great resources

4,16,17,18,19,20,21,22 Increased HIF activity in tubular epithelial cells prior to the onset of a toxic or ischemic renal insult appears to diminish the severity of tubular injury, which should be a beneficial effect, but increased expression of HIF in tubular epithelial cells has also been shown to trigger interstitial fibrosis, which is linked to loss of kidney function

These are most noted in the first day or two after increasing a dose or after consuming a high-fat, high sugar meal