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It can be generalized that at the beginning of MASL development, the expression/ activity of antioxidant enzymes generally increases to protect organisms against increased ROS production

Porcine (pig) insulin is especially close to the human version

In the two lymphoid cell lines, it was shown that all studied polyphenols when used in combination with each topoisomerase II inhibitor caused a synergistic or additive decrease in cell proliferation, G 2 M or S phase cell-cycle arrest and apoptosis