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Food and Drug Administration approval or undergone rigorous scientific testing

Gastrointestinal Effects The most commonly reported adverse effects are gastrointestinal in nature, including: Nausea and vomiting (affecting 20-40% of patients initially, varying by agent and dose) [8] Diarrhoea or constipation Abdominal discomfort and bloating Reduced appetite In elderly patients, persistent nausea and vomiting can lead to dehydration and electrolyte imbalances more rapidly than in younger adults

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a stable 13 C-labeled fatty acid breath test) and reliance on self-reported symptoms rather than validated symptom indices for gastrointestinal disorders are also limitations