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The hepatic enzyme acylpeptide hydrolase (APEH) facilitates conversion of VPAGLUC back to VPA, markedly impairing the drug's elimination and prolonging its half-life
Classically, after ingestion of certain agents like sulfamides, antipyretics, nitrofurans and antimalarial medicines, like the primaquine and chloroquine, the patient develops fever, black color urine, ictericia and anemia
PMID: 34579623[PubMed Reference] Bock-Marquette I, Saxena A, White MD, et al
4) Underexplored therapeutic strategies and model limitations: Preclinical studies have relied on in vitro mesangial cell models and lack validated animal models that fully recapitulate human IgA nephropathys pathological features (e.g., glomerular IgA1 deposition and mesangial proliferation)
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