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Drug resistance remains one of the leading bottlenecks contributing to unsatisfactory therapeutic outcomes and eventual treatment failure during clinical cancer chemotherapy, and abundant preclinical evidence has confirmed that abnormally elevated NNMT expression is closely correlated with acquired drug resistance across various solid and hematologic malignancies

Wang S, Qiao H, Wang P, Wang Y, Qin D (2021) ZDHHC19 is dispensable for spermatogenesis, but is essential for sperm functions in mice

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Launched: TRANSCAN-4 JTC 2026 Translational Research on Cancer Metabolism: Multidisciplinary Approaches for Diagnosis and Treatment CIHR and the Cancer Research Society are partnering to support Canadian researchers in this call, which aims to support the development of innovative, personalized approaches for cancer diagnosis, patient stratification, and treatment, grounded in a deeper mechanistic understanding of metabolic alterations in cancer