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Mechanisms investigated Metabolic-pathway research converges on a small set of enzymatic and receptor targets, and these compounds map onto different ones they are not interchangeable: NNMT inhibition (5-Amino-1MQ): studied as a small-molecule inhibitor of nicotinamide N-methyltransferase, an enzyme implicated in cellular NAD/SAM metabolism

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As there are a certain proportion of patients who do not actually lose significant weight with semaglutide treatment, it may potentially be worthwhile to keep these patients on therapy for this reason despite not losing weight. This study gives us more information on the timing of the cardiovascular benefit of semaglutide