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MBX Biosciences Sector: Precision Endocrine Peptide platform for obesity and rare endocrine disorders HQ: Carmel, IN Year Founded: 2018 Origin Story: MBX Biosciences is an Indiana University faculty-created startup founded by Peter Kent Hawryluk and Richard D

After deep anaesthesia with isoflurane (Attane Vet, 1,000 mg g 1 , ScanVet, Piramal Critical Care) mice were decapitated and the brain was removed and submerged in ice-cold aCSF (124 mM NaCl, 5 mM KCl, 1.2 mM Na 2 HPO 4 2H 2 O, 2.7 mM CaCl 2 2H 2 O, 1.2 mM MgSO 4 (anhydrous)), 10 mM dextrose, 26 mM NaHCO 3 was adjusted to pH 7.4 and an osmolarity of 298302 mOsm kg 1 after saturation with carbogen (95% O 2 /5% CO 2 )

Curcumin also reduces chronic inflammation at the molecular level by downregulating inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)

The program is live: it took effect July 1, 2026 and runs through December 31, 2027