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Interestingly, in vitro taurine-derived neuronal differentiation and its remarkable neuroprotective role in cerebellar granule cells have already been demonstrated and the mechanism would involve the regulation of cytoplasmic free calcium and intramitochondrial calcium homeostasis [56, 57]

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More recently, a long-acting exendin-4-based analog bound to the Fc portion of immunoglobulin G (IgG) known as efpeglenatide is under clinical development, and would also be suitable for a once-weekly injection [8,9]

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