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doi: 10.1038/nbt.2089

Delayed treatment with 4-methylpyrazole protects against acetaminophen hepatotoxicity in mice by inhibition of c-jun n-terminal kinase

Given the increased expression of cysteine catabolic enzymes, such as cystathionine -synthase (CBS), cystathionine -lyase (CSE) and 3-MST in different cancer cell types, it is likely that their relevance for cancer development is shared between the production of H 2 S (detailed later in the article) and the accompanying generation of metabolites that constitute carbon sources

Synthetic Lethal Screening Identifies Compounds Activating Iron-dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells