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Standard once-daily dosing spaced 24 hours apart is sufficient to maintain therapeutic efficacy while minimizing systemic exposure and simplifying protocol adherence
The percentages of subjects who were hospitalized for HF were 4.0 and 4.2% in the lixisenatide and placebo group, respectively (HR 0.96
Endocrinol., 165(3):569-577, 2000
Its the result of a tangled web of dysfunction involving: Insulin resistance: cells stop responding to insulin, leaving glucose in the bloodstream Excess glucagon: the liver keeps pumping out sugar, even when its not needed Low-grade inflammation: which damages tissues and disrupts metabolic signaling Impaired appetite regulation: driven by hormone imbalances and gut-brain miscommunication GLP-1 (glucagon-like peptide-1) helps untangle this web
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