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The longer isoform alone is known to act as a Rab GEF or Rab activating protein for Rab5 and Rac1GTPases, and it functions in endocytic mechanisms, endosomal dynamics, and micropinocytosis (Topp et al., 2004

10.1007/s00425-005-0214-8 135 TexeiraF

Growth factors such as (e.g., VEGF, platelet-derived growth factor [PDGF] bind to a receptor tyrosine kinase (RTK) on the cell membrane, causing autophosphorylation of the receptor, thus creating docking sites for intracellular signaling proteins

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