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PBS was used to bring total volumes to 1 mL

It is therefore important to keep in mind (1) the risk of over-basalization and (2) guideline recommendations that basal insulin therapy should be escalated to combination injectables when the basal insulin dose exceeds 0.5 Units/kg BW/day

The drug mimics a hormone called GLP-1 that your body naturally produces

Component-Level Trial Findings CJC-1295 (without DAC, modified GRF 1-29) Phase 1 and Phase 2 work described: Dose-dependent GH elevation (2-10x baseline at studied doses, PMID 16352683) IGF-1 elevation of 1.5-3x baseline at 1-2 weeks Mild facial flushing post-injection in some participants No serious adverse events at studied doses CJC-1295 with DAC The DAC-modified version covalently binds to albumin, extending half-life to 5-8 days (PMID 16352683)