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By blocking NNMT, 5-Amino-1MQ drives several metabolic benefits: Boosts NAD Levels Inhibiting NNMT preserves more nicotinamide for NAD synthesis, leading to enhanced mitochondrial function, increased cellular energy output, and activation of sirtuins , the proteins involved in longevity and DNA repair

3.4 Gut microbiota involved in the gut-brain axis The gut-brain axis (GBA) is a complex network connecting the gut, gut microbiota, and their metabolic products with the nervous, immune, and endocrine systems

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In general, L-theanine could induce cancer cell apoptosis through the mitochondrial pathway, inhibiting the EGFR, NF-B, and other signaling pathways, downregulating MMP9, or upregulating Smad2 in cancer treatment