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The final reconstructions of holo-complex and sub-complex were resolved at 4.8 and 4 resolution, respectively

IV ALA Therapy: Delivers alpha lipoic acid directly into the bloodstream to support liver detoxification, reduce oxidative stress, and complement antioxidant protocols

Abbreviations KOA: Knee osteoarthritis LPS: Lipopolysaccharide FLS: Fibroblast-like synoviocytes AMPK: AMP-activated protein kinase CPT1: Carnitine palmitoyltransferase 1 Cyc: Cytochrome c ACLT: Anterior cruciate ligament transection NSAIDs: Non-steroidal anti-inflammatory drugs CoA: Coenzyme A SOD: Superoxide dismutase MDA: Malonaldehyde ATP: Adenosine-triphosphate ROS: Reactive oxygen species CCK-8: Cell counting kit-8 DMEM: Dulbeccos modified Eagles medium IL-1: Interleukin-1 siRNA: Small interfering RNA References Sharma L

Our study indicates that inability of Syn variants to refold into their native inert state likely causes chaperones to remain bound for extended periods beyond their biological timescale, thereby compromising normal chaperone activity