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Hypoglycemia is rare with monotherapy but can occur if combined with insulin or sulfonylureas

Mechanisms of Ageing and Development, 89 (3), 125-154

For example, vitamin D deficiencies are often treated with high-dose vitamin D injections or supplements that deliver over 50,000 IU of vitamin D, which is much more than the UL ( Though most supplement bottles provide recommendations regarding how much of a vitamin to take per day, needs can vary from person to person

After 6 months, methylmalonic acid (MMA) levels, the most specific marker for B12 activity of a food or supplement, went from 164 nmol/l to 169 nmol/l which is essentially no change and by itself would indicate no benefit of the multivitamin