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Organ and Gut Growth (with misuse) Prolonged or high-dose use may lead to non-specific cell growth in internal organs or the intestines, contributing to the "roid gut" or distended abdomen effect seen in some bodybuilders

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Their activation permits calcium influx and initiates intracellular signaling cascades involving calmodulin kinase II (CaMKII), cAMP Response Element Binding Protein (CREB) and MAPK, culminating in the transcription of genes required for long-lasting synaptic enhancement [208]