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doi: 10.1111/j.1567-1364.2010.00687.x 103 LiuH.ZhaoX.WangF.LiY.JiangX.YeM.et al

Neurobehavioral effects of liraglutide and sitagliptin in experimental models

Specific mechanisms include regulating key hepatic lipid metabolism factors and interfering with the Nrf-2/HO-1 signaling pathway, while reducing harmful metabolites and increasing beneficial metabolites by regulating multiple hepatic metabolic pathways such as glutathione metabolism, purine metabolism, pantothenate and CoA biosynthesis, ABC transporters, and the HIF-1 signaling pathway