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The proportion of participants achieving clinically meaningful weight loss thresholds at 48 weeks on the 12 mg dose: - 5% weight loss: 100% - 10% weight loss: 93% - 15% weight loss: 83% For comparison, placebo achieved 5% in 27%, 10% in 9%, and 15% in just 2%

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But in phase one, two, and three, about half of them get weeded out each time, so 52% make it through phase one, 36% through phase two, and only 62% through phase three

Mechanistically, the induction of beta cell replication in both humans and rodents by osteoprotegerin occurs through the modulation of the CREB and GSK3 pathways