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B12 injections are clinically indicated for patients with confirmed deficiency or malabsorption conditions, including those with pernicious anaemia, gastrectomy, ileal resection, Crohn's disease, or neurological symptoms related to B12 deficiency

It helps prevent and repair the damage to the gut lining caused by stress, injury, or certain medications

The absence of a safety mechanism or switch further increases the risk of severe or fatal side effects, such as tumor lysis syndrome and cytokine release syndrome (Jureczek et al., 2019)

IV administration might be chosen if you are already on IV fluids or need a very rapid correction of vitamin levels