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Deficiency of a more proximal enzyme in that metabolic pathway, homogentisic acid dioxygenase, the third enzyme, is associated with the medical condition alkaptonuria and the clinical condition is not associated with any hypertyrosinemia
Out of the 20 studies, 16 confirmed ASD diagnosis using the Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria
D-SIP also plays a role in the regulation of circadian rhythms
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