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Approximately 1.28 billion adults aged 30 to 79 worldwide are estimated to have hypertension, a significant portion of whom live in low- and middle-income countries, where access to advanced treatments like semaglutide may be limited

severe rash Symptoms of severe dehydration from persistent vomiting or diarrhea Sudden severe upper right abdominal pain, fever, or yellowing of the skin (possible gallbladder disease) Use in Pregnancy and Breastfeeding Semaglutide may cause fetal harm

Blocked intestines, known clinicially as ileus, is a serious and potentially fatal condition

Synthesis and characterization of GLP-1RAs@NPs-WYRGRL To enhance the local concentration, stability, and retention time of GLP-1RAs in the joint area, GLP-1RAs were encapsulated into silk fibroin nanoparticles (GLP-1RAs@NPs) and the surface of GLP-1RAs@NPs was further modified with the WYRGRL peptide, thereby developing GLP-1RAs@NPs-WYRGRL for the treatment of RA (Fig